Below are steps on using the CCleaner program written by Brian Lee.
Yes, CCleaner works very well with JAWS. The program is set up in a standard dialog box structure where you can use the tab key and shift-tab to move forward and backward through a dialog box. You can also use the Alt key with the underlined letter of a control to activate it so that you don't have to tab to the control and press spacebar or enter. For example, Alt-R activates the "Run" button, which starts the scanning and removal process for the page of the dialog box that is active, which is the Windows page when you first start the program. When you first use the program and press Alt-R a child dialog box will appear with the OK button in focus. If you use the tab key you can move to a checkbox for telling the program not to show this confirmation box, and check it by pressing spacebar. After checking the box tab to the OK button and press spacebar. JAWS will announce the percentage of completion as the program scans and removes items, but quite often after hearing "100 percent" scanning and removal will begin for another area of the computer, so you should wait a few seconds after hearing JAWS say 100 percent to see if it starts announcing percentage progress again. If you route the JAWS cursor to the PC cursor, do a page up, and use down arrow to the line under where the "Windows tab and applications tab" are shown, you will hear whether or not cleaning is complete. This might vary a little on different systems, but the scanning complete notice should be given on a line not far under the page tabs.
After you have made the PC cursor active again you can use tab or shift tab to move to where JAWS says "Windows tab" and use right arrow to move to the Applications page tab. Use Alt-R again to run the program in this page.
Before running the program you probably want to set the program to only remove the types of items you want removed. After opening the program and before invoking the "run" button, use Shift-tab to move to the tree view of choices. If you use the shift-tab then you will find the tree view of choices after you hear the page tabs announced. Use down arrow in the tree view and check or uncheck items using the spacebar. For example, if you don't want all cookies removed then be sure to uncheck the cookies choice. You can always remove tracking cookies with a different program such as Super Anti- Spyware or Ad-Aware. Keep using down arrow through the choices in the tree view and use spacebar to check or uncheck items. the checkmark means that those types of items will be removed, if not checked then those items will be left alone. I think you can feel pretty comfortable with the default settings, although if you don't want the recycle bin emptied then you might uncheck that item, or if you don't want "auto complete form history" deleted then you can uncheck that box, etc. The only one I have unchecked in the Internet Explorer list of items is the cookies choice, as I only want tracking cookies removed.
If you use tab key to move to the page tabs and right arrow to the "applications tab", you can then use shift-tab to move back to the tree view and find a list of programs that have cached temporary files that you can remove. If you want to uncheck any of these choices then use down arrow and uncheck the box, but I think that you probably will just want to leave the default settings.
After you have set your choices they will remain as set for subsequent times when you use the program. Each time you run the program you will only need to use the run command by pressing Alt-R for the Windows page of the dialog and then move to the applications page and perform the run command with Alt-R.
Take care and have a great day!